Vladimir A Mitkevich Selected Research

ribonuclease T(2)

11/2020	Antitumour Activity of the Ribonuclease Binase from Bacillus pumilus in the RLS40 Tumour Model Is Associated with the Reorganisation of the miRNA Network and Reversion of Cancer-Related Cascades to Normal Functioning.
9/2017	Binase treatment increases interferon sensitivity and apoptosis in SiHa cervical carcinoma cells by downregulating E6 and E7 human papilloma virus oncoproteins.
7/2013	Ribonuclease binase inhibits primary tumor growth and metastases via apoptosis induction in tumor cells.
12/2011	Sensitivity of acute myeloid leukemia Kasumi-1 cells to binase toxic action depends on the expression of KIT and АML1-ETO oncogenes.
10/2007	Binase induces apoptosis of transformed myeloid cells and does not induce T-cell immune response.

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Vladimir A Mitkevich Research Topics

Disease

17	Alzheimer Disease (Alzheimer's Disease) 12/2021 - 01/2016
9	Neoplasms (Cancer) 12/2021 - 06/2007
5	Amyloid Plaque 12/2021 - 09/2016
5	Hypoxia (Hypoxemia) 01/2019 - 09/2012
3	Neuroblastoma 01/2019 - 01/2016
3	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2014 - 07/2010
2	Neoplasm Metastasis (Metastasis) 11/2020 - 07/2013
2	Non-Hodgkin Lymphoma (Lymphosarcoma) 11/2020 - 07/2013
2	Amyloidosis 01/2018 - 01/2018
2	Melanoma (Melanoma, Malignant) 12/2017 - 07/2013
1	Heart Diseases (Heart Disease) 12/2021
1	Neuroinflammatory Diseases 12/2021
1	Hypertension (High Blood Pressure) 12/2021
1	Memory Disorders (Memory Loss) 08/2021
1	Williams Syndrome (Williams-Beuren Syndrome) 12/2020
1	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2020
1	Infections 10/2020
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 09/2017
1	Carcinoma (Carcinomatosis) 09/2017
1	Virus Diseases (Viral Diseases) 01/2016
1	Lewis Lung Carcinoma 07/2013
1	Leukemia 12/2011
1	Hypersensitivity (Allergy) 06/2007

Drug/Important Bio-Agent (IBA)

13	Amyloid (Amyloid Fibrils)IBA 12/2021 - 01/2016
12	Peptides (Polypeptides)IBA 12/2021 - 01/2016
6	Proteins (Proteins, Gene)FDA Link 08/2021 - 01/2016
5	Amyloid beta-PeptidesIBA 01/2021 - 01/2016
5	Ribonucleases (Ribonuclease)IBA 11/2020 - 06/2007
5	ribonuclease T(2)IBA 11/2020 - 10/2007
4	ZincIBA 01/2020 - 01/2017
4	Adenosine Triphosphatases (ATPase)IBA 01/2019 - 01/2016
3	IonsIBA 01/2020 - 01/2016
2	Glutathione Disulfide (GSSG)FDA LinkGeneric 01/2019 - 10/2017
2	EnzymesIBA 10/2017 - 01/2016
1	AcidsIBA 12/2021
1	Antiviral Agents (Antivirals)IBA 12/2021
1	LigandsIBA 08/2021
1	MethyltransferasesIBA 12/2020
1	MicroRNAs (MicroRNA)IBA 11/2020
1	Adenosine Monophosphate (AMP)IBA 10/2020
1	Antimicrobial PeptidesIBA 10/2020
1	AntibodiesIBA 07/2020
1	Laminin (Merosin)IBA 07/2020
1	Histidine (L-Histidine)FDA Link 01/2020
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2019
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2019
1	S-ethyl glutathioneIBA 01/2019
1	S-NitrosoglutathioneIBA 01/2019
1	UbiquitinIBA 01/2019
1	Cholinergic Agents (Cholinergics)IBA 01/2019
1	Sulfhydryl Compounds (Thiols)IBA 01/2019
1	Acetylcysteine (Siran)FDA LinkGeneric 01/2019
1	Caspase 3 (Caspase-3)IBA 08/2018
1	Etoposide (VP 16)FDA LinkGeneric 08/2018
1	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/2018
1	Carrier Proteins (Binding Protein)IBA 01/2018
1	thioflavin TIBA 01/2018
1	Trace Elements (Biometals)IBA 01/2018
1	Peptide FragmentsIBA 12/2017
1	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2017
1	Cytostatic AgentsIBA 12/2017
1	Pharmaceutical PreparationsIBA 12/2017
1	Cardiac GlycosidesIBA 10/2017
1	Cysteine (L-Cysteine)FDA Link 10/2017
1	InterferonsIBA 09/2017
1	Viral ProteinsIBA 09/2017
1	Oncogene Proteins (Oncogene Protein)IBA 09/2017
1	Protein AggregatesIBA 09/2016
1	src-Family KinasesIBA 01/2016
1	SodiumIBA 01/2016
1	PotassiumIBA 01/2016
1	ribonuclease Sa3IBA 01/2014
1	Caspase 8 (Caspase-8)IBA 07/2013
1	Adenosine Triphosphate (ATP)IBA 09/2012
1	Toxic ActionsIBA 12/2011
1	Proto-Oncogene Proteins c-kit (Proto-Oncogene Protein c-kit)IBA 07/2010
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 07/2010
1	RNA (Ribonucleic Acid)IBA 01/2010

Therapy/Procedure

4	Therapeutics 12/2021 - 06/2007
2	Intraperitoneal Injections 11/2020 - 07/2013
1	Intravenous Injections 01/2018
1	Injections 01/2018